Ampicillin Trihydrate Compacted

CAS No.: 7177-48-2 EINECS: 200-709-7

Molecular Formula: C₁₆H₁₉N₃O₄S.3(H₂O) Molecular Weight: 403.45

Molecular Structure:

Property：

The melting point of Ampicillin Trihydrate Compacted is 198-200 ºC .The water solubility of Ampicillin Trihydrate Compacted is 0.1-1 g/100 mL at 21 ºC.

Specifications：

Item	Index
Characters	White or almost white crystalline granule and powder
Identification	(1) The IR spectrum obtained with the substance to be examined corresponds with that obtained with reference standard (2) Should meet the requirment under water Appearance of Solution Reference Suspension II max.(1 mol/L hydrochloric acid)Reference Suspension II max.(2 mol/L ammonia)
PH	3.5-5.5
Specific Optical Rotation	+208~+305
Related Substances Dimethylaniline	20 ppm max
Water	12.0%~15.0%
Sulphated Ash	0.5% max
Bulk Density	0.65g/ml min
Assay	96.0%~102.0% C₁₆H₁₉N₃O₄S(Calculated on the anhydrous basis)

Usage:

Ampicillin is closely related to amoxicillin, another type of penicillin, and both are used to treat urinary tract infections, otitis media, uncomplicated community-acquired pneumonia, Haemophilus influenzae, salmonellosis and Listeria meningitis. Ampicillin is used with flucloxacillin in the combination antibiotic co-fluampicil for empiric treatment of cellulitis; providing cover against Group A streptococcal infection whilst the flucloxacillin acts against the Staphylococcus aureus bacterium. Of concern is the number of bacteria that become resistant to Ampicillin necessitating combination therapy or use of other antibiotics.

All Pseudomonas and most strains of Klebsiella and Aerobacter are considered resistant.

An ampicillin resistance gene is commonly used as a selectable marker in routine biotechnology. Due to concerns over horizontal gene transfer to pathogenic organisms in the wild, the European Food Safety Authority restricts use of this gene (among other resistance genes) in commercial genetically modified organisms. The gene responsible for degrading Ampicillin is called Beta Lactamase, in reference to the beta-lactam structure of Ampicillin and related drugs.

Package and Storage:

Ampicillin is packed in 25kg fiber drum with shelf life 3 years.

Keyword：

Ampicillin,D-(-)-6-(2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid trihydrate