Avermectin

CAS NO.: 71751-41-2 EINECS: N

Molecular Formula: C₄₈H₇₂O₁₄; C₄₇H₇₀O₁₄ Molecular Weight: 873.09

Molecular Structure:

Property：

The density of Avermectin is 1.16,the melting point of Avermectin is 150-155 ºC. The avermectins are a series 16-membered macrocyclic lactone derivatives with potent anthelmintic and insecticidal properties. These naturally occurring compounds are generated as fermentation products by Streptomyces avermitilis, a soil actinomycete. Eight different avermectins were isolated in 4 pairs of homologue compounds, with a major (a-component) and minor (b-component) component usually in ratios of 80:20 to 90:10. Other anthelmintics derived from the avermectins include ivermectin, selamectin, doramectin and abamectin

Specifications：

Item	Index
Description	White crystalline powder
Identification	Meet the criterion
Loss On Drying	0.2%max
PH	4.50-7.50
Residue On Ignition	0.1%max
Heavy Metals	0.001%
Arsenic Salt	0.0002%
Assay	B1(B1a+B1b) 95.0%min. B1a 90.0%min.

Usage:

A commonly used therapy in recent times has been based on oral or parenteral administration of avermectins . They show activity against a broad range of nematodes and arthropod parasites of domestic animals at dose rates of 300 microgram/kg or less. Unlike the macrolide or polyene antibiotics, they lack significant antibacterial or antifungal activity.

Mechanism of Action
The avermectins block the transmittance of electrical activity in nerves and muscle cells by stimulating the release and binding of gamma-aminobutyric acid (GABA) at nerve endings. This causes an influx of chloride ions into the cells leading to hyperpolarisation and subsequent paralysis of the neuromuscular systems. GABA-ergic receptors are found at the neuromuscular junctions and the central ventral cords in nematodes, whereas in mammals it found primarily in the brain. Ivermectin does not readily cross the blood brain barrier in mammals at therapeutic doses.

Avermectin therapy is not without its drawbacks. Resistance to avermectins has been reported, which suggests use in moderation. Research on ivermectin, piperazine, and dichlorvos in combinations also shows potential for toxicity. Avermectin has been reported to block LPS-induced secretion of tumor necrosis factor, nitric oxide, prostaglandin E2, and increase of intracellular concentration of Ca2+.

Other uses
Abamectin is the active ingredient in some commercial ant bait traps

Package and Storage:

Keep in shaded, cool 25kg fiber drum and air places. The shelf time is 2 years.

Keyword：

Abamectin ,Mixture of Avermectin B1a and Avermectin B1b; Affirm; Agri-Mek; Avermectin; Avermectin B1; Avid; Zephyr