Colistin sulphate

CAS NO.: 1264-72-8 EINECS: 215-034-3

Molecular Formula: 2(C₅₂H₉₈N₁₆O₁₃).5(H₂SO₄) Molecular Weight: 2801.27

Molecular Structure:

Property：

Melting point 200-220 ºC. There are two forms of colistin available commercially: colistin sulfate and colistimethate sodium (colistin methanesulfonate sodium, colistin sulfomethate sodium). Colistin sulfate is cationic; colistimethate sodium is anionic. Colistin sulfate is stable, but colistimethate sodium is readily hydrolysed to a variety of methanesulfonated derivatives. Colistin sulfate and colistimethate sodium are eliminated from the body by different routes. With respect to Pseudomonas aeruginosa, colistimethate is the inactive prodrug of colistin. The two drugs are not interchangeable.

Specifications：

Item	Index
Potency	Dried Basis 19000IU/mg min.
PH Value	4.0-6.0
Residue On Ignition	1.0%max
Loss On Drying	3.5%max
Optical Rotation	-63。--73。
Assay	77%min.
Sulfate	16.0-18.0%
E3	10.0%max.
E1-I	10.0%max.
E1-7MOA	10.0%max.
Related Substances	4.0%max.
Total Related Substances	23.0%max.

Usage:

Colistin sulphate is used to treat certain stomach, bowel and digestive tract infections. Cyclic polypeptide antibiotic produced by Bacillus polymyxa. Complex mixture of at least 30 components, primarily colistins A and B. [a]D= -65?(c= 1, Water) LOD: 3%. Colistin sulfate may be used to treat intestinal infections, or to suppress colonic flora. Colistin sulfate is also used as topical creams, powders, and otic solutions

Package and Storage:

25kg fiber drum and kept in cool and air place for 2 years.

Keyword：

Colistin sulphate; N-[3-Amino-1-[[1-[[3-amino-1-[[6,9,18-tris(2-aminoethyl)-3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]carbamoyl]propyl]carbamoyl]-2-hydroxy-propyl]carbamoyl]propyl]-5-methyl-heptanamide sulfate