Dicloxacillin Sodium

CAS NO.: 13412-64-1 EINECS: N

Molecular Formula: C₁₉H₁₆C_l2N₃NaO₅S.H₂O Molecular Weight: 510.3

Molecular Structure:

Property：

Dicloxacillin Sodium is an oral semisynthetic isoxazolyl antistaphylococcal penicillin. Like other antistaphylococcal penicillins.Dicloxacillin Sodium is stable against penicillinase,.Dicloxacillin Sodium is active against many of the penicillinase-producing strains of Staphylococcus aureus

Specifications：

Item	Index
Characters	A white or almost white crystalline powder
Identification	A.IR spectrum complies with that of reference standard(IR ) B. Reaction(a) of sodium
Appearance of solution	A. Solution is clear B. ≤0.04
pH (2.5g/25ml H2O)	5.0 ～ 7.0
Specific optical rotation	+128°～ +143° ( calculated with reference to the anhydrous substance)
Related substances (HPLC)	Any impurity: for each impurity, not more than the area of the principal peak in the chromatogram obtained with reference solution(1per cent); Total: not more than 5 times the area of the principal peak in the chromatogram obtained with reference solution(5per cent)
N’N-Dimethylaniline	≤20ppm
2-Ethylhexanoic acid	≤0.8％
Content of Dicloxacillin Sodium(HPLC)	95.0 ～101.0 %
Pyrogens	Meets the requirements
Sterility	Meets the requirements

Usage:

Dicloxacillin Sodium is used mainly in the treatment of infections caused by these organisms. Dicloxacillin Sodium is the most active of the isoxazolyl antistaphylococcal penicillins. Clinical uses of Dicloxacillin Sodium include skin and soft-tissue infections, bone and joint infections, and urinary and respiratory tract infections. Dicloxacillin Sodium, because of its side chain, resists destruction by beta-lactamases. This makes it useful for treating bacteria that resist penicillin due to the presence of penicillinase. Dicloxacillin Sodium is ineffective, however, against methicillin-resistant S. aureus (MRSA). These organisms appear to resist Dicloxacillin Sodium and related antistaphylococcal penicillins due to the presence of a relatively insensitive PBP, although this mechanism is not fully understood.

Dicloxacillin Sodium is extremely active against most strains of penicillinase-producing Staphylococcus aureus and some strains of Staphylococcus epidermidis. As mentioned above, methicillin-resistant strains of staphylococci are resistant. The antistaphylococcal penicillins are active against group A streptococci and Streptococcus viridans, but the natural penicillins are more potent against streptococci and are preferred. The antistaphylococcal penicillins have limited activity against gram-negative and anaerobic bacteria and are not recommended for treating these infections. Clinicians are advised to consult susceptibility data to determine Dicloxacillin Sodium activity.

Package and Storage:

25kg fiber drum

Keyword：

Dicloxacillin sodium

Sodium 7-[3-(2,6-dichlorophenyl)-5-methyl-oxazol-4-yl]carbonylamino-3,3-dimet hyl-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylate