Florfenicol

CAS No.: 73231-34-2 EINECS: N

Molecular Formula: C₁₂H₁₄Cl₂FNO₄S Molecular Weight: 358.21

Molecular Structure:

Property：

The melting point of Florfenicol is 153 ºC. Florfenicol (marketed by Schering-Plough Animal Health under the trade name Nuflor) is a fluorinated synthetic analog of thiamphenicol.

In the United States, florfenicol is currently indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, and Haemophilus somnus, for treatment of bovine interdigital phlegmon (foot rot, acute interdigital necrobacillosis, infectious pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus

Specifications：

Item	Index
Appearance	White or almost white crystalline powder
Melting Point	152ºC-156 ºC
Specific Optical Rotation	-16º~-19 º
PH	4.5-6.5
Chlorides	0.02%max.
Fluorides	4.8% min.
Related Substances	Individual Impurity 0.5% max.
Total Impurities	2.0% max.
Water	0.5% max.
Residue On Ignition	0.1%
Heavy Metals	Less than or equal to 20 millionths
Assay	Not less than 98.0% of C₁₂H₁₄Cl₂FNO₄S,calculated on the dried basis

Usage:

The use of florfenicol in horses, and likely in other equids, typically causes diarrhea. This has been anecdotally reported to progress to lethal cases of acute colitis. Therefore, use of this antimicrobial in the equine patient should be limited to cases in which other, safer, options are not available

Package and Storage:

Florfenicol is packed in 25kg or 5 kg fiber drum with shelf life 2 years.

Keyword:

Florfenicol,
[R-(R*,R*)]-N-[1-(Fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide;2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide