Oxytetracycline Hydrochloride

CAS NO.: 2058-46-0 EINECS: 218-161-2

Molecular Formula: C₂₂H₂₄N₂O₉.HCl Molecular Weight: 496.90

Molecular Structure:

Property:

The melthing point of Oxytetracycline hydrochloride is 180°C.The storage temp. of Oxytetracycline hydrochloride is 0-6°C.The form of Oxytetracycline hydrochloride is crystalline.The color is yellow.The water solubility : >100 g/L. Oxytetracycline hydrochloride is Odorless fluffy yellow solid or yellow powder. Bitter taste.

Oxytetracycline hydrochloride is hygroscopic. Water soluble. Undergoes slow hydrolysis in the presence of water. Concentrated aqueous solutions at neutral pH hydrolyze on standing. Reactivity Profile

Oxytetracycline hydrochloride is sensitive to light. Oxytetracycline hydrochloride may be unstable at temperatures above 77° F. Oxytetracycline hydrochloride darkens on exposure to sunlight or to moist air above 194° F. Concentrated aqueous solutions at neutral pH hydrolyze on standing. Oxytetracycline hydrochloride undergoes hydrolysis in the presence of water. Oxytetracycline hydrochloride may be incompatible with alkalis.

Fire Hazard

Flash point data for Oxytetracycline hydrochloride are not available. Oxytetracycline hydrochloride is probably combustible.

Specifications：

Item	Index
Description	Yellow crystalline power
Identification	a) TLC results
	b) colour reaction with sulphuric acid
	c) reaction of chlorides
PH value (1%w/v)	Between 2.3 and 2.9
Absorbance at 353 nm (pH 2.0)	Between 270 and 290
Specific optical rotation	Between -188 and -200
Heavy metals	Not more than 50 ppm
Light absorbing impurities	Absorption at 430 nm shall not be more than 0.50
	Absorption at 490 nm shall not be more than 0.20
Related substance

Impurity A	Not more than 0.5%
Impurity B	Not more than 2.0%
Impurity C	Not more than 2.0%
Impurity D,E and F	Not more than 2.0%
Sulphated ash	Not more than 0.5%
Water content	Not more than 2.0%
Assay( caculated on anhydrous product)	Between 95.0% and 102.0%

Usage:

Oxytetracycline is an antimicrobial drug which possesses a wide range of antimicrobial activity against gram-positive and gram-negative bacteria, including some microorganisms innately insensitive to many chemotherapeutic agents, such as rickettsiae, mycoplasma, chlamydia agents of lymphogranuloma venerum, psittacosis, inclusion conjunctivitis, and trachoma and amebae. Oxytetracycline is also used in treatment of intestinal amebiasis; it removes both cysts and motile forms from intestine and compares favorably with arsenicals and halogenated quinolines.

PROPRIETARY NAMES

Oxytetracycline Hydrochloride is an active ingredient in the following proprietary drugs: Terramycin Vet Capsules, Terramycin Animal Formula, Terramycin Soluble Powder, Terramycin Ophthalmic Ointment with Polymyxin, iquamycin Injectable, Terramycin Injectable, Health TM-100 Type A Medicated Article, Health TM-100D Type A Medicated Article, Health TM-50 D Type A Medicated Article, Health TM-50 Type A Medicated Article.

DOGS Oxytetracycline Hydrochloride is used in dogs for the treatment of bacterial pneumonia caused by Brucella bronchiseptica, tonsillitis caused by Streptococcus hemolyticus, bacterial enteritis caused by Escherichia coli, urinary tract infections caused by Escherichia coli, and wound infections caused by Staphylococcus aureus. The drug can be used for continuation of compatible antibiotic therapy following parenteral oxytetracycline administration where rapidly attained, sustained antibiotic blood levels are required. The duration of treatment required to obtain favorable response will depend to some extent on the severity and degree of involvement and the susceptibility of the infectious agent. Clinical response to antibiotic therapy usually occurs within 48 to 72 hours.

CATS Oxytetracycline Hydrochloride is used in cats for the treatment of bacterial pneumonia caused by Brucella bronchiseptica, tonsillitis caused by Streptococcus hemolyticus, bacterial enteritis caused by Escherichia coli, urinary tract infections caused by Escherichia coli, and wound infections caused by Staphylococcus aureus.

Toxicity This antibiotic is capable of crossing the placenta and causing staining of the deciduous teeth. It stains to a lesser degree than tetracycline.

Package and Storage:

Keep in shaded, cool 25kg fiber drum and air places. The shelf time is 4 years.

Key Words:

Oxytetracycline hydrochloride ,5-Hydroxytetracycline hydrochloride; [4S-(4alpha,4aalpha,5alpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide monohydrochloride